NT5DC3 and neoplasm: Considering the anti-tumor effect of NT5DC3 gene in tumor models especially in colon cancer has not be clearly uncovered yet, the study on this novel factor might be beneficial to colon cancer pretreatment in clinical area, therefore, we primarily defined NT5DC3 as the candidate tumor suppressor in inhibiting colon cancer and preliminarily identified the regulation of LF on NT5DC3 (Additional file 2: Fig. S2C–E).