Due to the two Fe3 + binding sites in its structure, lactoferrin can be divided into the apo-type (without iron atom), a single-type (binding with 1 iron atom), and the holo-type (binding with 2 iron atoms), which have been proved to be tightly related to its bioactivities including anti-inflammation, anti-oxidation, anti-virus and anti-tumor [19–21]. This evidence concerns the gene LTF and neoplasm.