LF was proved to destroy the bridge between T2D and colon cancer through the suppression of epigenetic modification levels of 5mC (CpG island 1) and m6A (2309) of NT5DC3. We also found that WTAP played a key role in m6A (2309) of NT5DC3, which subsequently affect the expression levels of NT5DC3/HKDC1. Here, HKDC1 is linked to colonic neoplasm.