The secretory protein angiopoietin-like protein 2 (ANGPTL2) is a member of the angiopoietin-like family that plays vital roles in multiple physiological and pathological states, including angiogenesis [26, 27, 28], lipid metabolism [29], obesity [30], thrombosis [31], atherosclerosis [32] fibrosis [33] and tumor metastasis [34, 35] Our previous study demonstrated that ANGPTL2 was a ligand for the immune-inhibitory receptor human leukocyte immunoglobulin-like receptor B2 (LILRB2), maintained the stemness of hematopoietic stem cells (HSCs) and enhanced leukemogenic activities [36]. The gene discussed is ANGPTL2; the disease is obesity due to melanocortin 4 receptor deficiency.