Among them, MYC overexpression (MYCOE) transcriptionally and cellularly resembled primitive neuroectodermal tumors of the central nervous system (CNS-PNETs), while the remaining three (CDKN2A–/–/CDKN2B–/–/EGFROE/EGFRvIIIOE, TP53–/–/PTEN–/–/NF1–/–, EGFRvIIIOE/CDKN2A–/–/PTEN–/–) resembled GBM. This evidence concerns the gene CDKN2A and glioblastoma.