We then speculate that in NB tumor, a condition characterized by chronic exposure of catecholamines, the β2-AR subtype on TILs, the most expressed physiologically, may undergo downregulation following desensitization, and conversely the β3-AR earns the pivotal role in mediating the catecholamine-induced pro-tumoral effects. The gene discussed is ADRB3; the disease is neuroblastoma.