Finally, differential gene expression analysis on a public dataset (GSE14880 from GEO archive) consisting of 34 patients affected by NBs, confirmed that NB tumor masses with a low expression of ADRB3 showed a positive regulation of immune responses, T cell activation, and immune effector pathways compared to tumor mass with high levels of ADRB3 (Fig. 6D). Here, ADRB3 is linked to Nijmegen breakage syndrome.