Moreover, protein expression of the β3-AR on murine lymphocytes of NB-bearing mice were confirmed by western blot analysis of lymphocytes obtained from TDLNs (Supplementary Fig. 2A) and immunofluorescence of CD4+ and CD8+ T cells stained for β3-AR on tumor mass sections (Supplementary Fig. 2B). This evidence concerns the gene CD8A and neoplasm.