Considering that literature data recognized TILs as the main cellular source of IFN-γ during adaptive immune response [24], and that our results revealed that β3-AR modulation on N2A tumor cells did not affect the IFN-γ-dependent PD-L1 expression, we wondered if a β3-AR modulation on TILs was responsible of an altered IFN-γ secretion, which in turn affected the PD-L1 expression on tumor cells. Here, ADRB3 is linked to neoplasm.