Importantly, by examining the expression of the CXCL8 gene, miRNA-194-5p, and its target gene (SLC16A9) on intestinal cancerous and inflammatory tissue samples by RT-qPCR method, we found that two new genes, CXCL8, SLC16A9 with increased expression in cancerous and inflammatory samples, they have a potential diagnostic value to indicate the occurrence of CRC and are related to the prognosis of CRC, and they are critical and valuable for the progression of UC to colorectal adenoma and colorectal cancer and should be confirmed in future studies. This evidence concerns the gene CXCL8 and colorectal carcinoma.