CXCL1 and colorectal carcinoma: At the same time, our research shows that CXCL1 and CXCL8 as hub gene with high degree and effect; Also, mir-194-5p and miR-378a-5p, which target and regulate the central hub gene SLC16A9, have continuous changes in the progression of UC towards CRC, and all of them have diagnostic value.