Also, this analysis had 8 critical pathways out of 15 significant pathways in CRC, which are mainly related to MYC-targets, MTORC1 signaling, Angiogenesis, G2M checkpoint, E2F targets, IL6_JAK_STAT3, Mitotic spindle, and TNFA signaling pathways. Here, TNF is linked to colorectal carcinoma.