Yin Yang 1 (YY1)-binding micropeptide is translated by m6A-modified LNC00278 with the help of YTHDF1, which blocks the interaction between YY1 and the androgen receptor AR, reduces the expression of eEF2K through the AR signaling pathway, increases the level of caspase-3, and causes ESCC cells to undergo apoptosis. This evidence concerns the gene YY1 and esophageal squamous cell carcinoma.