Since SYNE2 encodes a nesprin protein, which affects the mechanical properties of the actin cytoskeleton69,70, and ESR2 is not expressed in cardiac samples, our results suggest that the most likely mechanism underlying the association between rs2738413 and atrial fibrillation involves changes in the expression of SYNE2 in cardiac muscle cells. Here, SYNE2 is linked to atrial fibrillation.