SYNE2 and atrial fibrillation: For example, the cardiac muscle- eQTL signal for SYNE2 (Figs. 2g, 5b–d), a gene that encodes for protein included in the nesprin family that links organelles and nuclear lamina to the actin cytoskeleton59, colocalized with an atrial fibrillation GWAS signal (PPA = 98.3%).