IRF1 and blood pressure trait: IRF1 is involved in cardiac remodeling and its overexpression is associated with cardiac hypertrophy53 and rs2549009 is in LD (R2 = 0.764) with rs7734334, a diastolic blood pressure-associated SNP54, suggesting a likely role of the gene pair IRF1/IRF1-AS1 in driving cardiac remodeling in response to high blood pressure.