Tspan32 deficiency increases IL2 secretion and promotes T-cell proliferation, but significantly diminishes the ability to generate pathogen-specific T cells.18TSPAN32 expression is significantly reduced in memory T cells from patients with multiple sclerosis,19 and in activated B cells and plasma cells in systemic lupus erythematosus patients.20 These studies suggest that TSPAN32 plays an important role in autoimmune diseases with potential to become a diagnostic marker or therapeutic target. This evidence concerns the gene TSPAN32 and systemic lupus erythematosus.