Curcumin significantly reduces the expression of MMP3 and 5-LOX in the synovium, reduces serum malonaldehyde levels, and increases the levels of the antioxidant enzymes SOD, CAT and GPX, thereby attenuating osteoarthritis.234 Furthermore, a compound(s) in rose hip inhibits 5-LOX activity and proinflammatory metalloproteinases and shows the potential to be a treatment for osteoarthritis;235 that is, curcumin and rose hip may show the potential to alleviate chondrocyte ferroptosis by inhibiting LOX activity. This evidence concerns the gene SOD1 and osteoarthritis.