LOX catalyzes the oxidative capacity of esterified PUFAs to generate lipid hydroperoxide LOOH, resulting in ferroptosis.224 LOX inhibitors, such as baicalein and zileuton, can increase cortical and total BMD, the trabecular area, and the number of trabecular nodes by inhibiting LOX activity and increasing the bone formation rate,231 making baicalein and zileuton promising therapeutic options for osteoporosis. Here, LOX is linked to osteoporosis.