Licofelone is an inhibitor of 5-LOX activity and is currently in clinical development for the treatment of osteoarthritis.232 It has been reported to modulate MMP13 production in human osteoarthritic chondrocytes,233 implying that licofelone may alleviate chondrocyte ferroptosis by inhibiting lipid peroxidation. This evidence concerns the gene ALOX5 and osteoarthritis.