GPX4 and osteoporosis: Extracellular vesicles derived from induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) have been extensively studied in recent years.253,254 For instance, BM-EPC-derived extracellular vesicles have been shown to increase the expression of GPX4 and SLC7A11 and attenuate the pathological changes in the steroid-induced osteoporosis context by suppressing ferroptotic pathway activity.144 Therefore, cell therapy or therapy with cell-specific extracellular vesicle may be approaches to alleviate ferroptosis-related osteoporosis.