Quercetin increased the expression of GSH and GPX4 in rats with osteoarthritis by reducing the levels of MMP3 and MMP13 and maintaining the integrity of the extracellular matrix of articular cartilage.255 Nifedipine, a voltage-gated calcium channel inhibitor, activates the Nrf2 pathway to reduce oxidative stress, prevent cartilage degeneration and improve osteoarthritis.256 Exosomes derived from bone MSCs can regulate chondrocyte glutamine metabolism by regulating c-MYC and improving chondrocyte functional factors, such as type II collagen and aggrecan, thereby alleviating osteoarthritis. Here, ACAN is linked to osteoarthritis.