Furthermore, this process depends on the direct combination of the Nrf2:c-JUN heterodimer, and targeting HO-1 or ferroptosis can successfully reverse osteocyte ferroptosis in the diabetic microenvironment by breaking the vicious cycle of HO-1 activation and lipid peroxidation, ultimately attenuating osteoporosis.128,142. This evidence concerns the gene HMOX1 and osteoporosis.