As expected from previous studies [12], Notch3 protein staining in the breast cancer epithelial compartment was weak (only 28.6% of tumor tissues had a strong staining intensity compared to 75% (15/20) of the normal tissues) (Fig. 1B), whereas it was strong in stromal cells and in the vascular system (Fig. 1A). The gene discussed is NOTCH3; the disease is breast cancer.