CDK1 and neoplasm: CDK1, the only gene included in the 4 enriched gene sets, displayed the most significant association with metastatic risk in a combined analysis that included both cohorts (OR = 9.01, 95% CI = 5.17–15.71, P = 8.5 × 10−15; Supplementary Fig. 5d; Fig. 4d); furthermore, high expression of CDK1 showed a strong association with shorter TTP, regardless of the tumor genomic subtype (HR = 4.15, 95% CI = 2.32–7.24, P = 1.1 × 10−6; Fig. 4e).