In agreement, we observed a significantly higher TMB in larger tumors, and in those with >5% Ki67 positive cells and high MKI67 expression levels (Fig. 2g–i); no association was detected between the MSI score and the tumor volume or the % of Ki67 positive cells (Supplementary Fig. 3d, e), probably due to the low number of tumors included in this analysis, but a significant association between the MSI score and the MKI67 expression levels was identified (Supplementary Fig. 3f). The gene discussed is MKI67; the disease is neoplasm.