When tumors were small (volume under 200 mm3), adoptive cell therapy (ACT) of low numbers (5 × 105) of decitabine-pretreated CD45.2+OVA-specific CD8+ TCROT-I cells could eliminate tumors, while control T cells initially suppressed tumor growth but tumors began growing after 12 days (Figure 1D). This evidence concerns the gene CD8A and neoplasm.