WWC1 and Glomerular sclerosis: Histological analysis of kidney sections from mice that were sacrificed and perfused 6 weeks after ADR revealed segmental and global glomerular sclerosis in 6 out of 13 KIBRA-OE mice, while only 1 out 9 control mice demonstrated segmental sclerosis, and the remainder of the control mice had normal-appearing glomeruli (Figure 4B).