Among patients with ILD, 27% (n = 12 of 44) of patients were identified with potential germline predisposition variants in telomere maintenance (TERT, n = 3; RTEL1, n = 5; PARN, n = 2; including 1 patient with both RTEL1 and TERT variants) or surfactant genes (SFTPA1, n = 1; SFTPA2, n = 1; SFTPC, n = 1), all of which were heterozygous and putatively autosomal dominant (Supplemental Table 5). This evidence concerns the gene RTEL1 and interstitial lung disease.