In a number of malignancies, including oesophageal cancer [24], breast cancer [25], lung cancer [26], and cervical cancer [27], retinoblastoma-binding protein 6 (RBBP6), which regulates cell proliferation, cell cycle, and cell apoptosis, is greatly up-regulated and is associated with poor clinical prognosis. The gene discussed is RBBP6; the disease is breast cancer.