We also evaluated the antitumor effects of knockdown of NCOA3-p300-NF-κB components by establishing a tumor xenograft model by injecting Control-KD1, RelA-KD1, NFKB1-KD1, p300-KD1, or NCOA3-KD1 cells (T47D background) into nude mice. The gene discussed is EP300; the disease is neoplasm.