IL6 and chronic obstructive pulmonary disease: Interestingly, high levels of IL-6 have been shown to induce the systemic release of NETs in other inflammatory diseases of respiratory disease such as severe asthma and chronic obstructive pulmonary disease (Lachowicz-Scroggins et al. 2019; Winslow et al. 2021), and statins may reduce IL-6 release under inflammatory conditions (Loppnow et al. 2011).