CD8A and isolated hemihyperplasia: Taken together, these findings suggest that while a generic pattern of decreased CD8+ cells but not Treg cells in B-cell–enriched IH is observed regardless of their location, Treg cells may have a bigger impact on the regulation of CD8+ cells in intratumoral IH compared with peritumoral IH, due to the presence of negative correlation between CD8+ T-cell and Treg abundance exclusively in intratumoral IH.