For example, in Drosophila, DCM was observed in mutants of genes encoding contractile and structural muscle proteins such as Troponin I (TpnI), Tropomyosin 2 (Tm2), δ‐sarcoglycan and Dystrophin but also associated with deregulations of EGF, Notch, Cdc42 and CCR4‐Not signaling pathway components (reviewed in Wolf, 2012). This evidence concerns the gene CDC42 and familial dilated cardiomyopathy.