For example, in Drosophila, DCM was observed in mutants of genes encoding contractile and structural muscle proteins such as Troponin I (TpnI), Tropomyosin 2 (Tm2), δ‐sarcoglycan and Dystrophin but also associated with deregulations of EGF, Notch, Cdc42 and CCR4‐Not signaling pathway components (reviewed in Wolf, 2012). Here, PROS1 is linked to familial dilated cardiomyopathy.