The role of TLR4 in platelets was further confirmed in sickle cell anemia patients, where HMGB1/TLR4 signaling increased platelet NLRP3 inflammasome activity in affected patients,45 as well as in sepsis patients, where GSDMD‐dependent platelet pyroptosis induced NET formation via S100A8/A9 and TLR4.46 This evidence concerns the gene TLR4 and sickle cell disease.