We imagine that by altering cell envelop architecture, Mtb tune their interactions to achieve the desired host response Garcia-Vilanova et al., 2019; for example, for initial infection and persistence, it may benefit the bacilli to minimize the TLR2-driven inflammatory response to promote immune evasion, whereas in order to drive tissue pathology and transmission, the bacilli may generate a hyperinflammatory phenotype (Chandra et al., 2022). The gene discussed is TLR2; the disease is infection.