The OR for progression to dementia after adjusting for age, MoCA, hypertension, triglycerides, HDL and diabetes duration remained 6.1 (95% CI: 1.6–23.8) times higher with abnormal CNFD and 4.1 (95% CI: 1.2–14.2) times higher with abnormal CNBD but was no longer significant with abnormal CNFL (2.3, 95% CI: 0.7–8.3, p = 0.19), hippocampus (3.7, 95% CI: 0.6–22.5, p = 0.16), and whole brain volume (5.4, 95% CI: 0.7–44.6, p = 0.12) (Table 3 and Fig. 2). The gene discussed is DOCK3; the disease is dementia.