DDIT3 and cancer: Indeed, during the induction of apoptosis in cancer cells, panaxydol was found to trigger the pro‐apoptotic transcription factor CHOP through the PERK/eIF2a/ATF4 signalling pathway, which subsequently activated Bim (a pro‐apoptotic transcriptional target of CHOP), thereby enabling apoptotic signalling from the ER to the mitochondria.