In the case of PTEN, being the main controller of angiogenesis, its active form in the endothelial cells is crucial for tumour angiogenesis normalization32 which, in turn, is vital to alleviate the reduced level of oxygen tension in the treatment of hypoxia‐dependent diseases, such as cancer, diabetes and cardiac and neurodegenerative diseases.18 The gene discussed is PTEN; the disease is diabetes mellitus.