During development, multiple guidance cues can control the guidance of axons to their specific targets and help establish functional neural circuits, such as netrin‐1 (NTN‐1)/deleted in colorectal carcinoma (DCC), Slit3/robo, Semaphorin5A/plexin, and ephtinB/ephB pathways.13 Here, DCC is linked to colorectal carcinoma.