Although the parameter they used is different, it yields the same conclusion, making the choice of the C-peptide and TyG index biomarkers of value in evaluating acne patients as it is well known that HOMA index calculation requires fasting insulin levels [13], which are more difficult to collect and not readily available in all laboratories compared to the C-peptide, triglyceride, and glucose levels required for the calculation of the TyG index. The gene discussed is INS; the disease is acne.