INS and acne: On the other hand, a study done by Munichandrappa et al. did not find any significant correlation between acne and insulin resistance [18], which contradicts our results and many of the published studies; the reasons for that can be the small population size and the fact that the bulk of patients mainly belonged to the mild category of acne, while in our study, we took patients with moderate-to-severe acne vulgaris, as about two-thirds of our cases were moderate-to-severe.