In addition, ACE2 promotes the conversion of angiotensin I into angiotensin II [[1], [2], [3], [4], [5], [6], [7], [8], [9]], which has protective effects against cardiac and vascular remodeling and prevents the development of pulmonary hypertension by reducing apoptosis and inflammatory responses [13,14]. The gene discussed is AGT; the disease is pulmonary arterial hypertension.