EGLN1 and neoplasm: It has also been previously found that HIF1A stabilizing long non-coding RNA (HISLA) in macrophages provides stability to HIF-1a by inhibiting its binding to the prolyl hydroxylase domain-containing protein 2 (PHD2) protein, thereby preventing its degradation and thus maintaining continuous activation of the aerobic state in tumor cells through HIF-1a signaling [138].