APOH and steatosis: Figure S4 indicated the significant metabolic alterations in patients with chronic HBV infection. However, lipid metabolic dysbiosis and HBV-related liver injury also influence gut microbiota hemostasis10. ,35,36 In addition, physiological processes are differentially regulated between men and women. Sex-specific ApoH deletion in mice promoted HBsAg secretion, disturbed lipid metabolism, and aggravated hepatocyte steatosis.