A study examining the sensitivity and kinetics of ZIKV NS1-based ELISA among travelers with ZIKV infection demonstrated higher IgM sensitivity of 79% in the first month and 68% up to two months post-symptoms onset [88] suggesting that levels of IgM against the NS1 may be declining much faster than IgM antibodies against the envelope protein. This evidence concerns the gene CD40LG and Zika virus infectious disease.