Includes 189 family trios;HBsAg(+), anti-HBc(+), but anti-HCV(−);Free of HDV and HIV infection;Free of other liver diseases, including autoimmune or toxic hepatitis, primary biliary cirrhosis, and Budd–Chiari syndrome;rs10272859: associated with the overall survival of 192 patients with HCC. This evidence concerns the gene KRT88P and hepatocellular carcinoma.