Includes 159 family trios;HBsAg(+), anti-HBc(+), but anti-HCV(−);Free of HDV and HIV infection;Free of other liver diseases, including autoimmune or toxic hepatitis, primary biliary cirrhosis, and Budd–Chiari syndrome;Replication phase: 4 cohorts with pooled results;rs17401966: associated with the KIF1B protein and mRNA expression. The gene discussed is KIF1B; the disease is primary biliary cholangitis.