Consequently, patients with severe COVID-19 have considerably higher blood levels of IL-2, IL-6, TNF-α, IL-1, IL-10, IFN-γ, IL-8/CXCL8, and CXCL10/IP-10 during the cytokine storm, potentially because of NF-κB via selective activation. The gene discussed is NFKB1; the disease is COVID-19.