In COVID-19 patients, TNFSF14/LIGHT is up-regulated along with Oncostatin M (OSM): a pleiotropic inflammatory cytokine of the IL-6 family, and Calgranulin C (S100A12), a calcium-, zinc- and copper-binding protein that plays a key role in the regulation of inflammatory processes and immune response. This evidence concerns the gene TNFSF14 and COVID-19.