These intracellular immune complexes, which are made up of pattern recognition receptors (PRRs), such as the absent in the melanoma 2 (AIM2)-like receptor (ALR) and NLR, the apoptosis-associated adapter protein, a CARD-containing dot-like protein (ASC), and pro-caspase-1, can be activated by a variety of internal or external stimuli, including bacterial and viral infection. The gene discussed is AIM2; the disease is viral infectious disease.