In this context, NLRP1 inflammasome detects SARS-CoV-2 infection in human lung epithelial cells, and its products, executioner Gasdermin D (GSDMD) and caspase-3, have been characterized as potential markers of severe pneumonia due to autoantibodies against or inborn errors of type I interferons (IFNs) [21]. Here, GSDMD is linked to pneumonia.