In this sense, the following lines of evidence have shown that NLRP3 was involved in COVID-19: the NLRP3 inflammasome responds to SARS-CoV-2 infection and is associated with the severity of COVID-19 in patients; the activation of the NLRP3 inflammasome is linked to a COVID-19-related cytokine storm and is triggered by the SARS-CoV-2 N protein; the age-induced over-stimulation of the NLRP3 inflammasome increases the lethality of SARS-CoV-2 pneumonia in elderly patients [19]. Here, NLRP3 is linked to COVID-19.