The mediators IL-1β, IL-6, IL-10, TNF-α, IL-8/CXCL8, IL-1RA, IL-18/IGIF, and sTNFR1 were all increased in patients with COVID-19 and followed the rate of elevation as clinical worsening progressed [54,55,65]. This evidence concerns the gene CXCL8 and COVID-19.