By binding to the bradykinin 1 receptor (B1R), the increased levels of [des-Arg9]bradykinin, specifically in the context of COVID-19, contribute to severe lung injury, pulmonary inflammation and oedema, increased coagulation, hypertension, and cardiac hypertrophy, which are all characteristics of COVID-19-affected patients [4]. This evidence concerns the gene BDKRB1 and cardiac hypertrophy.