The parallel use of the double-deleted Vaccinia virus (vvDD) or MYXV expressing the IL15Rα-IL15 fusion protein with other combinations such as rapamycin, celecoxib, and specific glioma neoantigen (GARC-1), resulted in a higher efficacy in GL261 murine glioma models [171]. The gene discussed is IL15; the disease is central nervous system cancer.