SEM1 and viral infectious disease: For example, the transcriptional analysis of Arabidopsis plants infected with geminivirus cabbage leaf curl virus (CaLCuV) revealed that the viral infection induces the expression of several genes linked to repairing DSBs and DNA synthesis, including DSS1 (I), DSS1 (V), DMC1, POLD3, RPA1A, and RPA1E [14].