CD8A and Wilson disease: Thus, although we still do not understand the exact nature of CD8+ T-cell dysregulation upon AlHV-1 infection and which viral genes induce lymphoproliferation during WD-MCF, a body of evidence supports that WD-MCF lesions result from the proliferation and infiltration of latently infected CD8+ T lymphocytes that resembles a peripheral T cell lymphoma (Figure 6).