Nonetheless, and despite the difficulty of maintaining LGLs in culture long term, recent data have established that AlHV-1 targets CD8+ T lymphocytes and induces WD-MCF by promoting the activation and uncontrolled proliferation of infected cytotoxic T lymphocytes, which results in peri-vascular infiltration and associated lesions [24,27,41]. Here, CD8A is linked to Wilson disease.