ARV σA protein has been demonstrated to upregulate the expression of glutamate dehydrogenase (GDH), isocitrate dehydrogenase 3 subunit β (IDH3B) and HIF-1α in Vero cells, thereby activating glycolysis, promoting TCA cycle, and making host cells to produce more energy, which is conducive to virus replication and infection [16]. This evidence concerns the gene HIF1A and infection.