To understand whether σA protein regulates the expression of glut1 downstream through c-myc and HIF-1α to promote cancer cells to obtain more ATP, we inhibited the expression of c-myc and HIF-1α with shRNAs; subsequent to this, the effects of c-myc and HIF-1α on the expression of downstream glut1 protein were analyzed. This evidence concerns the gene HIF1A and cancer.