SKP1 and viral infectious disease: In addition, CLCuMuB βC1 protein can disrupt the integrity of the SKP1/Cullin1 (CUL1)/F-box (SCF) complex SCFCOI1 by interacting with s-phase kinase-associated protein 1 (SKP1), thereby disrupting plant ubiquitination and promoting viral infection and symptom induction [124].