GBP4 and central nervous system cancer: We used Hiplot Enhanced MA v0.1.0 analysis, which showed that the significantly differentially expressed genes (DEGs) were interferon-stimulated genes (ISGs), such as Ifit1, GBP4, etc., and inflammatory factors, such as CXCL10, Stat1, etc., which indicated that CVA6 maintained effective infections in human glioma (U251) cells and mouse brain (Figure 5B,C).