VWF and COVID-19: In an extended analysis of global hemostatic assays, critical illness was associated with increased levels and activity of vWF, levels of soluble P-selectin (marker of endothelial cell and platelet activation), levels of soluble CD40L, and activity of factor VIII in COVID-19 patients admitted to the ICU, and mortality was correlated with vWF and thrombomodulin [83].