Infection with the dual reprogrammed Acp6.9-chiA/polh-cath virus, in which chiA is expressed under the p6.9 promoter and v-cath under the polh promoter, led to earlier larval death and liquefaction relative to infection with AcEGFP, Acp6.9-chiA, or AcMNPV-Rep. The gene discussed is CHIA; the disease is infection.