Despite its limitations, the present study, performed in a population that underwent chest CT scan, blood gas analysis, and accurate biochemical evaluation, is the first one that investigates the somatotropic axis in relation to hepatic steatosis in SARS-CoV-2-infected patients and could provide a fascinating insight into the link between GH/IGF-1 axis impairment and lung disease severity in COVID-19 patients. This evidence concerns the gene IGF1 and Hepatic steatosis.