The infection of IFNβ promoter or MX1 promoter luciferase transfected cells demonstrated a 3-fold and 4-fold increase, respectively, in both IFNβ and MX1 promoter activity with VHSV Ia infection in G3BP1 KD cells compared to WT RTgill cells (Figure 6D,E). The gene discussed is IFNB1; the disease is infection.