SG are considered signaling platforms and specific antiviral stress granules (avSG) formed during virus infection localize antiviral proteins like PKR, retinoic acid-inducible gene I (Rig-I), melanoma differentiation-associated protein 5 (MDA5), 2′-5′ oligoadenylate synthetase (OAS) and Ribonuclease L to provide a platform for interaction with RNA ligands to enhance type 1 interferon (IFN) production and antiviral defense [20,33,34,35]. This evidence concerns the gene EIF2AK2 and viral infectious disease.