MYD88 and viral infectious disease: Following reports that viral infections increase MyD88-dependent signaling [65,66] with concomitant impairment of type- 1 IFN antiviral activities [66,67], Saikh and co-workers showed that MyD88 inhibition by 4210 amplified IFN-beta production in human glioblastoma astrocytes (U87MG cells) in a dose dependent manner [68].