The calculated hepatitis B-positive rate among first-time donors in clinical scenario 2 (likely chronic infection) was 61.9 per 100,000 (95% CI 46.5–80.8) and was over 20 times higher in clinical scenario 1/3 (1449.5 per 100,000 (95% CI 1370.7–1531.7)). Here, PPIB is linked to hepatitis A virus infection.