Our bivariable analyses suggested that among Class 2 participants, those who develop CKD were more likely to have history of SUD, be ART naïve, enrolled in the cohort between 2000 and 2004, younger at baseline, with a lower CD4 nadir closer to the end of follow-up, and a shorter time on TDF (p-values <0.05). The gene discussed is CD4; the disease is chronic kidney disease.