As such, the hamster and the ferret, both naturally compatible hosts for infections of the initial SARS-CoV-2 variants [29,30,31,32,33], as well as the mouse and the humanized mouse models for ACE2 (hACE2), have been used to demonstrate how, at the olfactory level, the virus did not directly target olfactory sensory neurons (OSNs) but rather the so-called sustentacular supporting cells (Figure 1a) [34,35,36,37,38,39]. This evidence concerns the gene ACE2 and infection.