CASP1 and infection: Despite the robust upregulation of the Mediterranean fever gene (Mefv) implicated in inflammasome formation [37] and proinflammatory cytokine release, inflammasome components such as the Apoptosis-associated speck-like protein containing a CARD (Pycard), Proline-serine-threonine phosphatase-interacting protein 1(Pspip1), Absent in melanoma 2 (Aim2), Caspase 1 (Casp1), and NLR family pyrin domain containing 3 (Nlrp3) were weakly modulated early in infection (Figure 2A).