As shown in the Figure 2B, many downstream effector genes such as Interleukin-1 receptor-associated kinase 1 (Irak1), Transcription factor (Jun), Mavs [Ips-1], Mitogen-activated protein kinase kinase 7 (Map3k7[Tak1]) were downregulated during infection. The gene discussed is MAP2K7; the disease is infection.