The mechanism underlying this phenomenon is likely due to the promoter regions of IFNG and TNF, the genes encoding IFN-γ and TNF-α, respectively, being hypomethylated in adaptive NK cells allowing for greater cytokine production upon AD stimulation through ITAM-coupled receptors such as CD16 expressed on adaptive NK cells [32,61,62]. The gene discussed is IFNG; the disease is Alzheimer disease.