ISG15 and infection: In BxPC-3 cells, infection with GoraVir showed a trend towards upregulation of ISG15 (29.19 ± 10.02-fold change (FC)) as well as ISG54 (5.57 ± 3.26 FC) compared to uninfected cells as well as HAdV-C5-infected cells, nearing statistical significance (p = 0.081 and p = 0.055, respectively) (Figure 4A).