Infection with HAdV-C5 also resulted in downregulation of ISG15 and ISG54 (0.14 ± 0.02 FC, p < 0.001, and 0.26 ± 0.03 FC, p < 0.001, respectively) compared to uninfected cells although not as strong as upon infection with GoraVir. The gene discussed is ISG15; the disease is infection.