In line with this notion, ST1 and ST2 infection was only minimally altered by simultaneous knockout of IFITMs 1-3 in the A549 cell line (Figure 7F), which is often used to study the effect of IFITM expression [30,33,51], and the effect did not reach significance, neither with nor without prior interferon induction of IFITM expression. This evidence concerns the gene SDCBP and infection.