AIM2 and infection: To determine whether infection was affected by inflammasome component deficiency THP-1 cells with engineered deletions of sensors NLRP3, IFI16 and AIM2, adaptor ASC or effector caspase 1 [35] were similarly studied (Figure 1C–G) and showed that primary human monocyte-derived macrophages and differentiated THP-1 cells could be infected with both WT and LAMV strains of MeV independent of inflammasome component deficiencies.